New Trial-Based Advances for Optimizing Outcomes in MAC Pulmonary Disease

The Mandate for Individualized Care in Persons with NTM Lung Disease and Limited Options<br><sub>When and How to Intensify Antimicrobial Therapies Based on Clinical Presentation and Microbial Testing</sub>

The Mandate for Individualized Care in Persons with NTM Lung Disease and Limited Options
_{When and How to Intensify Antimicrobial Therapies Based on Clinical Presentation and Microbial Testing}

Professor Christoph Lange, MD - Program Chair

Antimicrobial Decision-Making in MAC Lung Disease<br><sub>When Prompt Therapy is Preferred Over a “Watch and Wait” Approach in NTM Pulmonary Disease with Limited Options</sub>

Video

Antimicrobial Decision-Making in MAC Lung Disease
_{When Prompt Therapy is Preferred Over a “Watch and Wait” Approach in NTM Pulmonary Disease with Limited Options}

Professor Stefano Aliberti, MD

Video

Translating Results of New MAC Lung-Focused Trials Evaluating Quality-of-Life Improvements, TTP, and Microbial Conversion Metrics to Optimize Antimicrobial Drug Selection

Professor David E. Griffith, MD

Video

Applying New Trial-Based Evidence, Guidelines, and Individualized Approaches to Real World Management for MAC Lung Disease

Professor Christoph Lange, MD - Program Chair

Click Here to Download Slides

Program Medium
Internet-based program

Method of Physician Participation Utilized in Learning Process
There are no fees for participating and receiving CME credit for this activity. During the period September 10, 2024 through September 10, 2025, participants must 1) read the learning objectives and faculty disclosures; 2) study the educational activity, and are expected to view activity, totaling 1.0 hours, to successfully complete the activity and earn CME credit; 3) register and complete the evaluation form and post-test; 4) score 100% on the post-test; and 5) print out CME certificate.

Estimated Time to Complete Educational Activity
1.0 hours. Physicians must study the enduring activity, and are expected to view every segment to successfully complete the activity and earn CME credit.

Course Overview
In this web-based program, physicians will learn how recent developments in basic and clinical research have helped to advance the understanding and management of non-tubercular mycobacterial (NTM) pulmonary infection with mycobacterium avium complex (MAC)

Release Date
September 10, 2024

Expiration Date
September10, 2025

Intended Audience
This complimentary CME educational activity is designed for all healthcare providers (HCPs) involved in developing, delivering, consulting, and monitoring care for patients with non-tubercular mycobacterial (NTM) pulmonary infection with mycobacterium avium complex (MAC), including infectious disease specialists, pulmonary medicine specialists, and related clinicians.

Registration
Participation in this activity is complimentary, and clinicians are invited to view this CME-certified program and/or share this invitation with other colleagues, departmental staff members, and healthcare professionals.

Grantor Support
This activity is supported by an independent medical education grant from Insmed.

Accreditation Statement
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the UMASS Chan Medical School and CMEducation Resources, LLC. The UMASS Chan Medical School is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation Statement
The UMASS Chan Medical School, Office of Continuing Medical Education designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits(s). Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Policy on Faculty & Provider Disclosure
It is the policy of the UMASS Chan Medical School to ensure fair balance, independence, objectivity and scientific rigor in all activities. All faculty participating in CME activities sponsored by the UMASS Chan Medical School are required to present evidence-based data, identify and reference off-label product use and disclose all relevant financial relationships with those supporting the activity or others whose products or services are discussed. Faculty disclosure will be provided in the activity materials.

Program Faculty and Disclosure

Professor Christoph Lange, MD – Program Chair
Medical Director/Clinical Director
Research Center Borstel
Borstel, Germany

Speaker's bureau: Cellestis, Oxford Immunotech
Consultant: Oxford Immunotech

Professor Stefano Aliberti, MD
Professor in Respiratory Medicine
Humanitas University
Chief, Pulmonary Department
IRCCS Humanitas Research Hospital
Milan, Italy

Consulting: Bayer Healthcare, Grifols, AstraZeneca, Zambon, Chiesi, Insmed, GlaxoSmithKline, Menarini, ZetaCube Srl
Grants: Insmed, Fisher & Paykel

Professor David E. Griffith, MD
Professor of Medicine
National Jewish Health
Denver, Colorado, USA

Consultant, Contracted Research and Speaker: Insmed

Program Managers and Web Editor Disclosure
Program Managers Gideon Bosker, MD and Denise Leary have nothing to disclose.

Educational Objectives
Upon completion of this activity, participants will be able to:

Understand and discuss the epidemiology and disease burden for NTM-PD and MAC Lung Disease based on prevalence, susceptible populations, and strategies for confirming the diagnosis of NTM-PD in the EU setting
Outline the burden of MAC Lung Disease for patients and the healthcare system, especially in regions with high disease burden and poor recognition of this challenging condition
Detail the pathophysiology of MAC infection, with a focus on intra-cellular macrophage reservoirs and pulmonary mechanics and architecture, and their implications for routes of antimicrobial administration
Interpret and apply the Year 2020 Updated ATS/IDSA/ERS Guidelines for MAC and NTM Pulmonary Disease; and apply new antimicrobial guidelines and recommendations contained in the new ATS/IDSA/ERS clinical practice statements
Compare and differentiate between the mechanism of action and delivery systems of different antimicrobial formulations and how these MOA will affect microbial conversion and eradication in MAC lung disease
Identify patients and symptoms that suggest the need to evaluate and assess—microbiologically and radiographically—persons with COPD, bronchiectasis, history of TB and other co-morbid conditions that place them at high risk for acquiring MAC lung infection

Hardware and Software Requirements:
To participate in this program, viewers must have a PC or Macintosh computer that has active, ongoing internet access for the duration of the program, as well as a compatible Flash-viewer. An email address is required for registration, and a printer is required to print out the CME certificate.

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Reproduction, distribution, or translation without express written permission is strictly prohibited.
Content on this webcast reflects the opinions, output, and analyses of experts, investigators, educators, and clinicians whose activities for, while independent, are commercially supported by the sponsor noted at the start of each activity.
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