Neutrophil-Based Targeting in Non-Cystic Fibrosis Bronchiectasis (NCFBE)
^{Focus on Inflammation and Disease Activity}

Method of Physician Participation Utilized in Learning Process
There are no fees for participating and receiving CME credit for this activity. During the period July 28, 2026 through July 26, 2028, participants must 1) read the learning objectives and faculty disclosures; 2) study the educational activity, and are expected to view activity, totaling 1.0 hours, to successfully complete the activity and earn CME credit; 3) register and complete the evaluation form and post-test; 4) score 100% on the post-test; and 5) print out CME certificate.

Estimated Time to Complete Educational Activity
1.0 hours. Physicians must study the enduring activity, and are expected to view every segment to successfully complete the activity and earn CME credit.

Course Overview
In this web-based program, physicians will learn about recent developments in the management of bronchiectasis.

Release Date
July 28, 2026

Expiration Date
July 28, 2028

Intended Audience
This complimentary CME educational activity is designed for all healthcare providers (HCPs) involved in developing, delivering, consulting, and monitoring care for patients with bronchiectasis, including pulmonologists, respiratory medicine specialists, infectious disease specialists, and related clinicians.

Registration
Participation in this activity is complimentary, and clinicians are invited to view this CME-certified program and/or share this invitation with other colleagues, departmental staff members, and healthcare professionals.

Grantor Support
This activity is supported by an independent medical education grant from Insmed.

Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the University of Massachusetts Chan Medical School and CMEducation Resources, LLC. The University of Massachusetts Chan Medical School is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation Statement

The University of Massachusetts Chan Medical School, Office of Continuing Medical Education designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits(s)^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Policy on Faculty & Provider Disclosure

It is the policy of the University of Massachusetts Chan Medical School to ensure fair balance, independence, objectivity and scientific rigor in all activities. All faculty participating in CME activities sponsored by the University of Massachusetts Chan Medical School are required to present evidence-based data, identify and reference off-label product use and disclose all relevant financial relationships with those supporting the activity or others whose products or services are discussed. Faculty disclosure will be provided in the activity materials.

Program Faculty and Disclosure

Professor James Chalmers Professor (Clinical), Molecular and Clinical Medicine
School of Medicine
University of Dundee School of Medicine
Dundee, Scotland, United Kingdom

Research grants or consulting fees: Astrazeneca, Boehringer Ingelheim, Chiesi, Gilead Sciences, Grifols, Insmed, Janssen, Novartis, Zambon

Program Managers and Web Editor Disclosure 
Program Managers Gideon Bosker, MD and Denise Leary have nothing to disclose.

Educational Objectives

Upon completion of this activity, participants will be able to:

• Understand the disease burden, unmet needs, lung function decline, patient risk factors associated with lung damage, QoL (quality of life) and comorbidities.
• Outline the natural history, signs, symptoms and clinical course, and impact of pulmonary exacerbations on progression of the disease.
• Improve their ability to recognize NCFBE early and accurately.
• Understand the diagnostic pathway that flags cardinal symptoms of NCFBE (e.g., chronic productive cough, recurrent exacerbations) to trigger timely diagnosis (eg CT scan).
• Avoid potential misdiagnosis with other common respiratory diseases (Chronic Obstructive Pulmonary Disease (COPD), asthma) and recognize ‘red flags’ and steps to minimize diagnostic delays.
• Explain the role of neutrophilic inflammation, and neutrophil serine proteases in the pathophysiology of NCFBE.
• Outline the latest approaches to bronchiectasis management, including emerging treatment modalities and appropriate use, and as part multi-modal treatment approach and the latest bronchiectasis guidelines.
• Discuss the global and local burden of NCFBE for patients and the healthcare system, especially in global regions—U.S., Europe, and Japan—with high disease burden and suboptimal recognition and delayed diagnosis of this challenging and widespread condition with high morbidity, poor treatment options, and significant mortality.

Hardware and Software Requirements:

To participate in this program, viewers must have a PC or Macintosh computer that has active, ongoing internet access for the duration of the program, as well as a compatible Flash-viewer. An email address is required for registration, and a printer is required to print out the CME certificate.

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Content on this webcast reflects the opinions, output, and analyses of experts, investigators, educators, and clinicians whose activities for, while independent, are commercially supported by the sponsor noted at the start of each activity. 

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